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通过混合纳米层对人工植入物进行表面修饰:抗菌表面加工和强度测试

Jiří Škach¹, Irena Šlamborová², Hana Jelínek Šourková³

¹Department of Surgery, Regional Hospital Liberec a.s., Liberec, Czechia.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

|October 25, 2023

概括

用抗菌纳米层修饰植入物的表面修饰改善了抗菌性质. 虽然机械强度略有下降,但在临床上仍然无关紧要,这为减少感染风险提供了有前途的方法.

科学领域:

生物材料工程生物材料工程
表面科学是一门学科.
医疗器械技术医疗器械技术

背景情况:

Hernia 植入物容易受到手术部位感染.
目前的植入物需要改进的抗微生物特性.
表面修饰提供了一种提高植入物性能的策略.

研究的目的:

为了评估植入物的表面修饰.
为了提高抗菌性质,使用带有抗菌金属子 (Ag,Cu,Zn) 的混合纳米层来改善抗菌性质.
评估纳米层应用和表面激活对机械性能的影响.

主要方法:

测试了常见的脏植入材料 (聚烯,聚,聚乙烯化物).
应用混合纳米层使用sol-gel方法与固定金属离子.
通过等离子体处理或UV-C辐射来激活植入物表面,以增强粘附性.
使用拉力测试测量机械性能 (强度,柔性).

主要成果:

等离子处理和紫外线辐射产生了令人满意的表面激活,最佳条件因网状材料而异.
一个抗微生物溶液 (AD30) 稀释 1:1 与异醇证明有效.
与原始植入物相比,修改后的网格显示了轻微的,临床上无意义的机械性能减少.

结论:

使用sol-gel方法修改植入物的表面是有效的,并且在技术上是可行的.
开发的纳米层技术显示了增强植入物抗感染能力的前景.
进一步的研究将集中在准备好的层的抗菌疗效和毒性.

关键词:

Hernia 这是一个.一个小小的网格.纳米层是一种纳米层.索尔凝方法的方法

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