在AF患者左心房关闭后的单一抗血小板治疗:安全性和有效性
Marc Llagostera-Martín1, Miguel Cainzos2, Neus Salvatella1
1Servicio de Cardiología, Hospital del Mar, Barcelona, Spain.
Revista espanola de cardiologia (English ed.)
|October 25, 2023
概括
在高风险患者的左心房附带关闭 (LAAC) 后,单次抗血小板治疗 (SAPT) 是安全有效的. 这一策略显著减少了缺血事件和严重出血,提供了一个有前途的替代抗血栓治疗方法.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 血栓形成的研究研究
背景情况:
- 对于非膜性心房动,左心房关闭后 (LAAC) 的最佳抗血栓治疗仍然没有定义.
- 接受LAAC治疗的患者往往具有高风险的缺血和出血事件.
研究的目的:
- 根据LAAC,评估单一抗血小板治疗 (SAPT) 策略的安全性和有效性.
- 评估SAPT对高风险患者缺血事件和出血的影响.
主要方法:
- 74名用LAmbre设备接受LAAC的患者进行了前性,观察性,单中心研究.
- 患者在SAPT上出院;主要结局是中风,全身栓塞和与设备相关的血栓形成的组合.
- 二级结局包括心血管死亡率和严重出血 (BARC ≥3a);随访包括临床评估和心声回声.
主要成果:
- 该队列具有高的CHA2DS2-VASc (中位数4) 和HAS-BLED (中位数4) 分数.
- 随访 (中位数2.5年) 显示,与设备相关的血栓形成 (4%) 和缺血性中风 (1.3%) 的发病率较低,风险显著降低.
- 严重出血发生在16%的患者中,与预测的风险相比,也显示出降低.
结论:
- 单一抗血小板治疗 (SAPT) 是左心房附属体关闭 (LAAC) 后安全有效的抗血小板治疗策略.
- 这种方法适用于患有缺血和出血并发症高风险的患者.
- 需要进一步的研究,以在更大的队列中验证这些发现.
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