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生物工程纳米技术用于核酸输送

Yang Zhang¹, Jing Luo², Xiran Gui³

¹State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Journal of controlled release : official journal of the Controlled Release Society

|October 25, 2023

概括

生物工程纳米载体为治疗癌症等疾病提供先进的核酸输送. 本综述强调了外体,蛋白质纳米和其他纳米载体,讨论了它们在临床应用中的潜力和挑战.

科学领域:

生物技术是生物技术.
纳米医学是一种纳米医学.
治疗方法治疗方法

背景情况:

基于核酸的疗法对遗传疾病,癌症和病毒感染有很大的前景.
现有的输送系统,如脂质纳米颗粒,已经取得了临床成功.
生物工程核酸输送纳米载体正在因其设计灵活性和生物相容性而受到关注.

研究的目的:

审查生物工程核酸输送纳米载体的最新进展.
专注于外体,细胞膜衍生的纳米纤维,蛋白质纳米,和类似病毒的粒子.
讨论它们的特点,优点,应用和临床翻译的挑战.

主要方法:

关于生物工程纳米载体用于核酸输送的最新进展的文献综述.
分析特定纳米载体类型的独特特性,优势和生物医学应用.
讨论临床翻译的挑战和未来方向.

主要成果:

外体,细胞膜衍生的纳米纤维,蛋白质纳米和类似病毒的粒子是关键的生物工程纳米载体.
这些纳米载体为核酸输送提供了独特的特性和优势.
它们的生物医学应用正在扩大,但临床翻译面临障碍.

结论:

生物工程纳米载体具有促进核酸治疗的巨大潜力.
需要进一步开发以克服临床翻译方面的挑战.
这个领域代表了医学纳米技术的一个有希望的前沿.

关键词:

生物工程纳米技术生物工程纳米技术细胞膜衍生的纳米纤维.异构体是什么? 异构体是什么? 外构体是什么?核酸输送核酸的交付方式蛋白质纳米中的蛋白质.类似病毒的粒子.

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