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在艾滋病毒感染妇女怀孕期间CD4计数的变化

Isabelle Boucoiran^1,2,3, Hélène C F Côté^4,5, Caroline Jodoin¹

¹Centre d'infectiologie mère-enfant (CIME), Centre de recherche du Centre hospitalier universitaire (CHU) Sainte-Justine (CR-CHUSJ), Montreal, Quebec, Canada.

|October 25, 2023

概括

怀孕期间CD4计数明显下降到200细胞/毫米3以下,对于感染艾滋病毒的妇女来说是不常见的. 初始CD4计数超过450细胞/毫米3的妇女在怀孕期间可能只需要一次监测会.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
产科和妇科产科和妇科

背景情况:

艾滋病毒感染妇女怀孕需要仔细监测免疫状况.
CD4计数是HIV阳性个体免疫功能的一个关键指标.

研究的目的:

为了确定CD4细胞计数在怀孕期间下降到200细胞/毫米3以下的频率,在感染艾滋病毒的妇女中.
为了确定与这种CD4计数下降相关的因素.

主要方法:

来自加拿大两组艾滋病毒感染的孕妇的数据分析 (2005-2020年).
根据国家指南,对CD4细胞计数进行了监测:每三个月一次,分娩时一次.
进行统计分析,包括单变量和多变量分析,以确定相关因素.

主要成果:

9.3%的妇女在第一次怀孕访问时CD4计数<200细胞/毫米3.
另有2.8%的患者在初始计数≥200细胞/mm3.3后,细胞数下降到<200细胞/mm3.
较低的CD4计数在首次访问时独立地与随后的下降有关. 第一次访问时的CD4计数≤450细胞/毫米3具有100%的灵敏度来检测下降到<200细胞/毫米3.

结论:

在怀孕期间,对于艾滋病毒感染的妇女来说,CD4计数下降到<200细胞/毫米3是不常见的.
在第一次怀孕检查时,CD4计数>450细胞/毫米3的妇女在怀孕期间只能安全地接受一次CD4监测.

关键词:

CD4 淋巴细胞计数数量艾滋病病毒艾滋病病毒艾滋病病毒抗逆转录病毒药物治疗怀孕怀孕怀孕怀孕怀孕女人女人女人女人女人

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