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三 (Tripterygium hypoglaucum) 提取物通过肠道微生物群在小鼠中改善辅助剂诱导的关节炎

Jianghui Hu¹, Jimin Ni¹, Junping Zheng¹

¹College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.

Chinese journal of natural medicines

|October 25, 2023

概括

三 (Tripterygium hypoglaucum,THH) 提取物通过调节肠道微生物群和阻断炎症通路来缓解类风湿性关节炎 (RA) 的症状. 它的抗RA作用取决于肠道菌群的存在,突出THH作为潜在的微生物调节器.

科学领域:

药理学药理学是指药理学的学科.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

类风湿性关节炎 (RA) 是一种慢性炎症性疾病.
三 (Tripterygium hypoglaucum,简称THH) 是一种传统的中国草药,用于治疗RA.
肠道微生物群在THH抗RA作用中的作用尚不清楚.

研究的目的:

研究THH提取物,肠道微生物群和抗RA作用之间的关系.
阐明THH在辅助剂诱导关节炎 (AIA) 的治疗作用背后的机制.

主要方法:

对THH提取物成分的HPLC-MS分析.
用THH提取物治疗AIA小鼠.
评估关节炎症,炎症媒介和肠道微生物群的组成.
使用抗生素诱导的伪无菌小鼠进行验证.

主要成果:

在AIA小鼠中,THH提取物显著降低了关节胀和软骨破坏.
THH通过抑制TLR4/MyD88/MAPK通路来调节炎症反应.
THH恢复了肠道微生物群的平衡,增加了有益的细菌,减少了有害的细菌.
在伪无细菌的小鼠中,THH的治疗效果被废除了,这证实了肠道微生物群的关键作用.

结论:

通过操纵肠道微生物群和调节TLR4/MyD88/MAPK信号通路,THH提取物具有抗RA作用.
肠道菌群对于THH在治疗关节炎的有效性至关重要.
THH提取物显示出作为RA治疗的微生物调节器的潜力.

关键词:

关节炎是一种关节炎.我们的肠道微生物群.豁免权是一种豁免权.炎症炎症是一种炎症.三 (Tripterygium hypoglaucum) 是指三体的下垂体部分.

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