应急部门的雾化药物:对非传统药物的叙事性审查
Kyle A Weant1, Regan A Baum2, Garrett B Hile3
1Department of Clinical Pharmacy and Outcome Sciences, University of South Carolina College of Pharmacy, Columbia, SC, USA.
概括
新兴的 nebulized 疗法提供快速,有效的急诊室 (ED) 治疗,副作用较少. 本综述探讨了新型气溶液药物及其管理细微差别,以改善患者护理.
科学领域:
- 药理学 药理学是指药理学的学科.
- 紧急医疗 紧急医疗
- 呼吸系统疗法 呼吸系统疗法
背景情况:
- 传统的药物治疗方法 (如静脉注射) 可能不适合所有急诊室 (ED) 患者.
- 雾化为ED环境中药物输送提供了一个有希望的替代方案.
- 气溶药物输送使药物能够直接向药物,可能增强治疗反应并减少全身副作用.
研究的目的:
- 总结一下新兴的非传统疗法,在ED中通过雾化进行治疗.
- 分析现有的关于在紧急护理中雾化药物管理的文献.
- 审查用于ED的新型非商业雾化药物治疗方法.
主要方法:
- 对新兴的ED使用雾化疗法的文献综述.
- 对影响雾化药物疗效的因素的分析.
- 检查新的雾化药物治疗方法.
主要成果:
- 在紧急情况下,雾化可提供快速,不那么侵入性的药物接入.
- 通过雾化直接输送可以增强治疗反应并最大限度地减少全身不良影响.
- 目前正在研究多种药物用于ED中雾化给药.
结论:
- 药剂师在管理床边雾化疗法的复杂性方面发挥着至关重要的作用.
- 对新型雾化药物的进一步研究可以扩大紧急护理中的治疗选择.
- 雾化代表了紧急医疗药物药理疗学的重大进步.
相关概念视频
01:23Inhaled Medications
288
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
288
01:18Drug Delivery: Enteral Route
468
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
468
01:30Adrenergic Agonists: Therapeutic Uses
824
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
824
01:20Inhalational Anesthetics: Overview
310
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
310
01:17Drugs Used in Lower Respiratory Disorders: Overview
458
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
458
01:22Drug Delivery: Miscellaneous Routes
359
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
359