壮症对甲状腺疾病的影响
1Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Endocrine journal
|October 25, 2023
概括
高增长激素 (GH) 和类似胰岛素的增长因子-1 (IGF-1) 在壮症中可能导致甲状腺问题. 向IGF-1受体 (IGF-1R) 显示出甲状腺相关眼科医症 (TAO) 治疗的前景.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
背景情况:
- 巨症的特征是生长激素 (GH) 和类似胰岛素的生长因子-1 (IGF-1) 的升高,可以导致甲状腺功能障碍,,结节和潜在的甲状腺癌.
- 甲状腺相关的眼病 (TAO) 是一种自身免疫性疾病,IGF-1受体 (IGF-1R) 在其发病过程中发挥着重要作用.
研究的目的:
- 为了研究GH/IGF-1对甲状腺健康的影响.
- 探索IGF-1R在TAO中的作用,并评估针对IGF-1R的潜在治疗策略.
主要方法:
- 审查现有的关于壮症,甲状腺功能障碍和TAO的文献.
- 对研究IGF-1R抑制剂的分析,如teprotumumab,在活性TAO中.
- 在相关组织中检查TSH受体 (TSHR) 和IGF-1R之间的相互作用.
主要成果:
- 过度的GH/IGF-1有助于子和结节的形成,可以通过使IGF-1水平正常化来逆转.
- IGF-1R抑制剂teprotumumab在具有活性TAO的患者中显示出显著的改善.
- TSHR和IGF-1R在轨道和甲状腺组织中形成一个功能复合体.
结论:
- 虽然壮症和甲状腺癌风险之间的联系仍在争论中,但建议定期查具有恶性潜力的结节.
- 准IGF-1R通路为TAO提供了一个有前途的治疗途径.
- 针对TSHR和IGF-1R的联合治疗可能比TAO的单剂治疗更有效.
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