构建可行的复合疾病活动测量的有效性和响应性,用于牛皮关节炎患者的日常临床实践
Fazira R Kasiem1, Marc R Kok2, Jolanda J Luime3
1Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands f.kasiem@erasmusmc.nl.
RMD open
|October 25, 2023
概括
3项和4项视觉模拟尺度 (3VAS和4VAS) 显示出在临床实践中测量牛皮关节炎 (PsA) 疾病活性的前景. 与现有措施相比,这些尺度显示出强烈的相关性和良好的歧视.
科学领域:
- 类风湿病学 类风湿病学
- 临床测量 临床测量
- 牛皮关节炎研究研究
背景情况:
- 牛皮关节炎 (PsA) 缺乏一种普遍接受的疾病活动测量标准,用于日常临床使用.
- 三项视觉模拟量表 (3VAS) 和四项视觉模拟量表 (4VAS) 是为了满足这一需求而开发的.
- 在早期的PsA患者中评估这些新措施至关重要.
研究的目的:
- 评估3VAS和4VAS的构造有效性和响应能力.
- 为了比较3VAS和4VAS与已建立的PsA疾病活动仪器的性能.
- 确定3VAS和4VAS在早期PSA的现实环境中的实用性.
主要方法:
- 利用了629名新诊断的PsA患者接受通常护理的数据.
- 使用斯皮尔曼相关性和标准化响应平均值 (SRM) 评估构造有效性和响应性.
- 对比3VAS/4VAS协议与其他复合措施 (DAPSA,DAS28,PASDAS,RAPID3) 低疾病活性 (LDA) 分类.
主要成果:
- 3VAS和4VAS都表现出对DAPSA和DAS28的可比响应 (ES=0.48,SRM 0.50-0.52).
- 在3VAS/4VAS和已建立的措施,如DAPSA (r=0.80-0.87),PASDAS (r=0.89) 和RAPID3 (r=0.84-0.92) 之间观察到强烈的相关性.
- 3VAS和4VAS在确定12个月LDA患者时与PASDAS达成最高一致.
结论:
- 3VAS和4VAS在评估PsA疾病活动方面表现出有希望的性能特征.
- 这些尺度表现出强烈的相关性和良好的区分能力与现有的复合措施.
- 在临床应用中,由于面部有效性可能更好,因此4VAS可能更可取.
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