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阻断MCT4增加了免疫检查点阻断的有效性

Nathalie Babl1, Sonja-Maria Decking1,2,3, Florian Voll1,3

  • 1Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.

Journal for immunotherapy of cancer
|October 25, 2023
PubMed
概括

单独准单碳酸盐运输体4 (MCT4) 能够逆转结直肠癌中乳酸驱动的免疫抑制. 这种策略通过改善T细胞功能和延长生存时间来增强免疫检查点阻塞 (ICB) 疗法.

关键词:
药物治疗,组合治疗.免疫检查点抑制剂 免疫检查点抑制剂免疫学监测 免疫学监测淋巴细胞,瘤透细胞代谢过程中的代谢.瘤微环境 瘤微环境

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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