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在Hunner类型的间歇性囊炎中,术后静脉内灌注治疗后的复发
Kwang Jin Ko1, Michael Jakun Koo1, Seokhwan Bang2
1Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
Scientific reports
|October 25, 2023
概括
在经尿道切除术后注入氨酸和氨酸硫酸可显著降低汉纳型间歇性囊炎的复发率. 此外,这种治疗还能维持症状的改善超过一年.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
- 再生医学是一种再生医学.
背景情况:
- 洪纳型间歇性囊炎 (HC) 在控制膀疼痛和尿路功能障碍方面构成了重大挑战.
- 目前用于HC的治疗方法,包括通过尿道切除,往往具有很高的复发率.
- 需要改进治疗策略,以减少HC复发并增强长期症状缓解.
研究的目的:
- 评估内注射的氨酸和里丁硫酸盐 (HACS) 灌注在通过尿道切除后的有效性,以减少Hunner型间歇性囊炎患者的复发率.
- 评估HACS灌注对HC患者症状改善和无复发生存时间的影响.
主要方法:
- 进行了一项前性单臂研究,比较HC患者接受过尿道切除加HACS灌注治疗 (HACS组) 与仅接受过尿道切除的历史对照组.
- 该研究包括78名患者,其中51人在每协议分析组中.
- 结果,包括复发率,无复发生存率和症状问卷得分,在两年内进行了分析.
主要成果:
- 与对照组 (86.2%,P < 0.001) 相比,HACS组的两年复发率 (47.1%) 显着较低.
- 灌注疗法将复发危险比率降低了0.38 (P < 0.001),HACS组中没有达到中位数无复发生存期,对照组为11.4个月.
- 虽然所有患者都出现了症状改善,但HACS组在12个多月内保持了稳定的改善.
结论:
- 经过尿道切除后的肠道HACS灌注是亨纳类型间歇性囊炎的有效辅助疗法.
- 这种治疗大大减少了疾病的复发,并为患者提供超过一年的持续性症状缓解.
- HACS灌注是一种有希望的策略,可以改善HC患者的长期结果.
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