血管激素转化酶I/D多态性不会影响稳定冠状动脉疾病患者的运动能力的训练诱导适应性
Tórur Sjúrðarson1,2, Jacobina Kristiansen3,4,5,6, Nikolai B Nordsborg2
1Center of Health Science, Faculty of Health, University of the Faroe Islands, Tórshavn, Faroe Islands.
Scientific reports
|October 25, 2023
概括
血管激素转化酶 (ACE) I/D多态性不会影响冠状动脉疾病 (CAD) 患者的运动能力或运动训练的改善. 这一发现表明,与ACE相关的遗传因素不能预测对心脏康复计划的反应.
科学领域:
- 心血管医学 心血管医学
- 人类遗传学 人类遗传学
- 运动生理学 运动生理学
背景情况:
- 系统的运动训练对于改善冠状动脉疾病 (CAD) 患者的运动能力至关重要.
- 然而,这些改善的程度在个体之间有很大差异.
- 在这种异质性中,遗传因素的作用,如血管素转化酶 (ACE) 基因插入/删除 (I/D) 多态性,尚未完全理解.
研究的目的:
- 调查ACE I/D多态是否影响稳定CAD患者的基线运动能力.
- 为了确定ACE I/D多态是否影响12周高强度运动训练计划后的运动能力增长.
主要方法:
- 一组169名患有稳定的CAD的患者随机分配到12周的运动训练组或标准护理组.
- 在128名参与者中,ACE I/D多态性被基因定型.
- 在干预期之前和之后测量了氧气吸收峰值 (VO2峰值).
主要成果:
- 不同的ACE I/D基因型组 (D/D,I/D,I/I) 之间没有观察到基线峰值氧气吸收的统计学上显著差异.
- 经过12周的运动训练,所有基因型组都显示出高峰氧气吸收的显著改善.
- 在所有ACE I/D基因型组中,运动能力增加的程度是可比的,这表明基因型和运动训练反应之间没有显著的相互作用.
结论:
- 在患有稳定的CAD的患者中,ACE I/D多态性似乎不是基线运动能力的决定因素.
- 这种特定的遗传多态性不会影响通过12周的高强度运动训练来提高运动能力.
- 这些发现表明,ACE I/D基因型不是在接受心脏康复的CAD患者中对运动反应的预测因素.
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