突尼斯儿童患有自闭症谱系障碍的肠道微生物群变化取决于年龄和严重程度
Mariem Chamtouri1,2, Naoufel Gaddour3, Abderrahmen Merghni4
1Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain.
Scientific reports
|October 25, 2023
概括
肠道微生物群的改变和特定的短链脂肪酸 (SCFA) 与自闭症谱系障碍 (ASD) 有关. 早期干预可以帮助缓解ASD儿童的肠道和神经发育问题.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 与肠道微生物群和短链脂肪酸 (SCFA) 改变有关.
- 了解不同人群中的这些变化对于开发有针对性的干预措施至关重要.
研究的目的:
- 分析突尼斯患有自闭症儿童的肠道微生物群和便SCFA概况.
- 将这些个人资料与兄弟姐妹 (SIB) 和一般人口 (GP) 进行比较.
- 研究这些变化的与年龄相关的差异.
主要方法:
- 肠道微生物群组成的metataxonomic分析.
- 便中SCFA水平的量化.
- 在不同年龄段 (4-7岁和8-10岁) 的ASD患者,SIB和GP组之间的比较.
主要成果:
- 与SIB和GP相比,ASD患者表现出不同的肠道微生物群概况.
- 较少的Bifidobacterium丰度是严重自闭症的关键特征,特别是在较小的儿童 (4-7岁).
- 与GP相比,在4-7岁的ASD患者中观察到较高的和酸水平,减少了8-10岁.
结论:
- 在ASD中,肠道微生物群的变化在较早的年龄更为明显,并倾向于随着时间的推移减弱.
- 这项研究强调了早期肠道健康干预在管理ASD相关的神经发育障碍方面的潜在作用.
- 这是对突尼斯自闭症儿童肠道微生物群的首次metataxonomic研究.
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