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带无血管区血管密度与视野进展有关,在早期的眼睛内,眼睛的绿内障与中部视野损伤有关

Jooyoung Yoon¹, Ko Eun Kim¹, Anna Lee¹

¹Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

Scientific reports

|October 25, 2023

概括

在早期的带有中部视力丧失的开角绿内障中,围绕状血管区 (FAZ) 周围的血管密度降低与视野下降的速度更快有关. 这种FAZ血管密度损失可能预测青光眼的进展.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
光学连贯性断层扫描血管学

背景情况:

开角玻璃眼 (OAG) 可以导致逐渐视野 (VF) 损失,特别是在具有中央视野 (CVF) 缺陷的眼睛中.
早期发现VF进展对于管理OAG至关重要.
光学连贯断层扫描血管造影 (OCT-A) 允许详细的图像的形无血管区 (FAZ) 血管.

研究的目的:

通过OCT-A测量FAZ相关参数与早期OAG眼睛中CVF缺陷的VF进展之间的关联.
确定潜在的生物标志物,以预测该患者群体的VF进展.

主要方法:

对131个具有CVF缺陷的早期OAG眼睛进行了纵向研究 (CVF平均偏差[MD]≥-6dB).
使用OCT-A评估了FAZ参数 (例如,在300μm环状区域的血管密度[FD300]) 和黄斑结节细胞内状层厚度 (mGCIPLT).
使用线性混合效应模型,Cox比例危险模型和线性回归来比较进展者和非进展者,并确定与VF进展相关的因素.

主要成果:

在平均3.45年的随访期间,在24.4%的眼睛中检测到VF进展.
与非进步者相比,进步者在FD300和mGCIPLT的减少率明显更快.
更快的VFMD或中央12个VF点的平均总偏差 (MTD10) 减少率与加速的FD300损失和mGCIPLT稀释相关联.

结论:

减少FD300显着与早期OAG眼睛中CVF缺陷的VF进展有关.
FD300可以作为辅助生物标志物来监测CVF缺陷的眼睛中的VF进展.

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