在患有唐氏综合征和自闭症谱系障碍的人群中,低维他命症D
Natalie K Boyd1, Julia Nguyen2, Mellad M Khoshnood1
1Division of Neurology, Children's Hospital Los Angeles, 4650 Sunset Blvd, MS82, Los Angeles, CA, 90027, USA.
Journal of neurodevelopmental disorders
|October 25, 2023
概括
唐氏综合征 (DS) 患者的维生素D水平低于自闭症谱系障碍 (ASD) 或神经类型 (NT) 对照患者. 在DS中,维生素D缺乏与更高的BMI和个人或家族自身免疫力有关.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 据报道,患有唐氏综合征 (DS) 的人群中血维生素D水平低.
- 现有的数据仅限于小,同质的队列.
- 在DS中自身免疫性疾病的高发病率强调了维生素D状况的重要性.
研究的目的:
- 在一个多中心的群体中调查维生素D的状况.
- 将DS患者的维生素D水平与自闭症谱系障碍 (ASD) 患者和神经类型 (NT) 对照者进行比较.
主要方法:
- 对维生素D25-OH水平的回顾性多中心审查.
- 包括通过ICD代码识别的DS,ASD和NT控制的个体.
- 使用了第一个记录的维生素D25-OH水平,以反映非补充状态.
主要成果:
- 与ASD (23.48 ng/mL) 和NT对照 (29.20 ng/mL) 相比,DS患者的维生素D25-OH水平 (20.67 ng/mL) 平均最低 (p < 0.001).与ASD (23.48 ng/mL) 和NT对照相比,DS患者的维生素D25-OH水平是最低的.
- 维生素D缺乏 (<30 ng/mL) 在24.6%的DS个体,28.3%的ASD和40.3%的NT对照中观察到 (p <0.001).
- 在DS患者中,较低的维生素D水平与较高的BMI,神经学诊断,个人自身免疫力和家族自身免疫力有关.
结论:
- 与ASD和NT个体相比,患有DS的个体表现出低维生素D.
- 在DS中发现了维生素D缺乏与BMI,个人和家族自身免疫力之间的关联.
- 这些发现凸显了对DS患者维生素D状况的监测的必要性.
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