与SARS-CoV-2的急性后续症状相关的危险因素:N3C和NIH RECOVER研究
Elaine L Hill1, Hemalkumar B Mehta2, Suchetha Sharma3
1Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Boulevard Box 420644, Rochester, NY, 14642, USA. Elaine_Hill@urmc.rochester.edu.
中年成人,女性和患有严重COVID-19的住院患者面临更高的SARS-CoV-2感染 (PASC) 后急性后果的风险,也被称为长COVID. 特定的并发症也会增加PASC的风险,这凸显了进一步研究的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 后急性SARS-CoV-2感染 (PASC) 或长期COVID的后续影响超过三分之一的人.
- 识别PASC的风险因素对于理解和管理这种情况至关重要.
研究的目的:
- 为了确定与PASC诊断相关的人口统计学,并发症和急性COVID-19相关因素.
- 分析风险因素,使用大型的,多系统的美国队列.
主要方法:
- 使用国家COVID队列协作 (N3C) 数据库进行回顾性病例控制研究.
- 匹配了8,325个PASC病例与31个美国卫生系统的41,625个对照病例.
- 使用多变量后勤回归,随机森林和XGBoost来识别风险因素.
主要成果:
- 中年 (40-69岁),女性性别和COVID-19住院治疗与增加PASC可能性有关.
- 严重的急性疾病指标 (长期住院,机械呼吸) 和并发症 (抑郁症,慢性肺病,肥胖) 增加了PASC风险.
- 年龄较小,男性性别,黑人种族和某些并发症与较低的PASC概率有关.
结论:
- 关键的PASC风险因素包括中年,严重的COVID-19和特定的并发症.
- 需要进一步的研究来阐明PASC机制以及疫苗和治疗等干预措施的影响.
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