胃口及其与晚期癌症患者死亡率的关联 - 从息性D研究的后期分析
Charlotte Goodrose-Flores1, Stephanie E Bonn2, Caritha Klasson3
1Division of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Huddinge, Karolinska Institutet, Stockholm, Sweden. Charlotte.goodrose.flores@ki.se.
BMC palliative care
|October 26, 2023
概括
晚期癌症患者的食欲丧失和疲劳预测死亡率更高. 低白蛋白和高CRP/白蛋白比率也表明风险增加,特别是在男性中,有助于缓解护理预后.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 临床营养学 临床营养学
背景情况:
- 失去食欲是晚期癌症患者的常见症状.
- 了解食欲轨迹有助于在息性癌症护理中的预后.
- 这项研究探讨了食欲,疲劳,白蛋白和CRP/白蛋白比率与死亡率的关联.
研究的目的:
- 调查在晚期癌症患者中自我评估的食欲和死亡率之间的关联.
- 为了检查疲劳,白蛋白水平,CRP/白蛋白比率和死亡率之间的关系.
- 探索这些关联中的潜在的性别差异.
主要方法:
- 对息性D研究 (530名晚期癌症患者) 的后期分析.
- 使用埃德蒙顿症状评估系统 (ESAS) 评估的食欲和疲劳.
- 考克斯的比例危险模型用于计算死亡风险的危险比率 (HR).
主要成果:
- 食欲不佳 (HR 1.78) 和严重疲劳 (HR 1.84) 显著增加了死亡风险.
- 低白蛋白 (<25 g/L) (HR 5.35) 和高CRP/白蛋白比率 (HR 2.66) 与更高的死亡率有关.
- 关联在男性中比在女性中更明显.
结论:
- 胃口不佳,严重疲劳,低白蛋白和高CRP/白蛋白比率与晚期癌症的死亡率增加有关.
- 这些因素可以作为有价值的临床工具,用于癌症息护理的预后.
更多相关视频
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.1K
13:35Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
10.5K
相关概念视频
Cancer Survival Analysis
357
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
357
Regulation of Food Intake
248
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
248
Kaplan-Meier Approach
154
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
154
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Taste Buds and Receptors
2.1K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.1K
Gastric Emptying
876
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
876
