剩余胆固醇与中风风险之间的非线性联系:来自中国健康与退休纵向研究的证据
Yuanqing Wang1, Fubing Zha2, Yong Han3
1Department of Functional Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, Guangdong, China.
这项研究发现,中国老年人残留胆固醇 (RC) 与中风风险之间存在积极的非线性联系. 较高的RC水平,特别是低于1.78mmol/L,显著增加中风的发生率.
科学领域:
- 心血管流行病学心血管流行病学
- 心血管风险的生物标志物
背景情况:
- 关于残留胆固醇 (RC) 和中风风险之间的关联是有争议的.
- 了解这种关系对于心血管疾病预防策略至关重要.
研究的目的:
- 调查残留胆固醇 (RC) 与发生中风风险之间的关联.
- 为了分析中年和老年人的中国人口中的这种关系.
主要方法:
- 利用10067名中国参与者 (中年和老年人) 的数据.
- 采用多变量考克斯比例危险回归,通用添加模型和光滑曲线拟合.
- 进行敏感性分析以验证发现.
主要成果:
- 在RC和中风风险之间观察到一个积极的关联 (HR=1.087).
- 确定了一种非线性关系,转折点为1.78 mmol/L.
- 脑卒中风险增加了25.1%,RC在1.78mmol/L以下的单位增加 (HR=1.251).
结论:
- 在被研究的人群中,残留胆固醇和中风风险之间存在正面和非线性关系.
- 这些发现有助于更好地了解RC在发生中风中的作用.
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