从芬太尼转换为摩的重症儿童的阿片类药物转换计算器的变化率
Madison Casten1, Jamie L Miller1, Stephen B Neely1
1University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.
概括
片转换计算器 (OCC) 在重症儿童中将芬太尼转换为水墨时显示出显著的变化. 由于这些不一致的阿片类药物转化结果,临床医生应谨慎行事.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 片转换计算器 (OCC) 是药物管理的重要工具.
- 精确的阿片类药物转化对于有效的疼痛管理和患者安全至关重要,特别是在脆弱的儿科患者群体中.
研究的目的:
- 量化和描述阿片类药物转换计算器 (OCC) 结果的变异性.
- 为了评估来自各种OCC的水利摩尔输液率的范围,在从芬太尼过渡的重症儿童中进行输液.
主要方法:
- 这是一项描述性,回顾性研究,分析了28名重症儿童 (<18岁) 的数据.
- 用十七种不同的OCC来计算从芬太尼的摩输液率.
- 计算的速率与先前研究中定义的摩稳定率进行了比较.
主要成果:
- 在17个OCC中观察到广泛的中位数海德罗摩速率范围 (0.06到0.12毫克/公斤/小时).
- 一些OCC组 (3和6) 经常高估了所需的摩剂量,而另一些 (4和5) 则低估了它.
- 在计算和稳定摩的剂量之间发现了显著的差异,突出显著的变化.
结论:
- 在不同阿片类药物转换计算器之间存在相当大的变化,用于儿科重症监护中将芬太尼转换为水墨.
- 这些发现强调了在这种患者群体中使用OCC时需要谨慎和批判性评估.
- 可能需要进一步的研究来标准化OCC或为儿科患者开发更可靠的转换方法.
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