导管辅助生物启发的粘合磁性软米利机器人用于药物输送
Xingyue Hu1,2,3, Yuting Zhou1,2,3, Mengyue Li1,2,3
1State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, Liaoning, 110016, China.
Small (Weinheim an der Bergstrasse, Germany)
|October 26, 2023
概括
这项研究介绍了一种用于向药物输送的新型软磁性毫米机器人. 这种适应性强的机器人可以通过导管引导,固定在组织上,并取回,克服了当前软型毫米机器人的局限性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 机器人技术 机器人技术 机器人技术
背景情况:
- 软型毫米机器人由于其适应性,在医学中提供了治疗潜力.
- 现有的软毫米机器人在精确的位置控制和激活后检索方面扎.
- 需要先进的千米机器人,能够在生物环境中控制进入,操作和移除.
研究的目的:
- 开发一种软磁性毫米机器人,用于有针对性的药物输送,具有增强的定和取回能力.
- 以自然系统为灵感设计了一种具有双层粘合体的毫米机器人.
- 为了在生物模型中证明米利机器人的操作可行性和药物输送效率.
主要方法:
- 制造一个双层千米机器人,使用一种以鱼为灵感的水凝和一种以章鱼为灵感的磁性结构层.
- 使用医疗导管进行受控的输入和取出,利用差异粘附特性.
- 采用外部磁场进行运动和水下组织粘附以进行定.
- 使用胃模型验证适应性和可回收性,并用超声波 (US) 影像检测隔离小肠以确定体内可行性.
主要成果:
- 毫里机器人成功地通过导管进行了受控的输入和取出,可适应空气和水环境.
- 在外部磁场下实现了自我展开和多模运动,具有有效的水下组织粘附.
- 在胃模型中证实了适应性和可回收性,展示了实际的实用性.
- 生物系统中的可行性在使用美国成像的孤立小肠中被证明是可行的.
- 通过光成像验证了高效的向药物输送.
结论:
- 开发的软磁性千米机器人解决了医疗应用现有技术的关键局限性.
- 它独特的设计允许精确的导航,安全的定和有效的药物输送到体内.
- 毫里机器人对未来的治疗干预和有针对性的药物输送系统有很大的前景.
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