一种新的家庭方法,用于制备抗结核病药物的悬浮剂
R Taneja1, M C Nahata2, J Scarim3
1Global Alliance for TB drug Development (TB Alliance), New York, NY.
概括
护理人员现在可以使用XTEMP-R设备在家中轻松准备液体结核病 (TB) 药物悬浮剂. 这种方法确保了儿童和无法吞结核病片的患者的准确剂量.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 儿科医学 儿科医学
背景情况:
- 药片是结核病 (TB) 治疗的主要剂型.
- 成人结核病片不适合儿童使用,原因是吞困难和需要精确剂量定位.
- 现有的儿童结核病药物管理方法往往是不够的.
研究的目的:
- 评估一种新型设备,XTEMP-R,用于制备结核病药物的液体悬浮剂.
- 评估将结核病药片转化为家庭使用的均悬浮剂的可行性和准确性.
- 确定 XTEMP-R 装置适用于儿科结核病治疗的适用性.
主要方法:
- 使用XTEMP-R装置将四种关键的结核病药物 (普雷托曼尼德,德拉曼尼德,克洛法齐明,贝达奎林) 分散在水和简单的糖中.
- 评估了从新制备的悬浮液中准确的分量配送的可重复性.
- 在储存悬浮剂2天后,重新评估了剂量递送的准确性.
主要成果:
- 所有测试的结核病药物的悬浮剂在大约10分钟内准备好,视觉上均的一致性.
- 剂量准确度为94.6%至101.1%的理论度,用于初始和两天存储的样本.
- XTEMP-R设备在清洗后显示药物残留量很小或不存在,这表明药物恢复效率高.
结论:
- XTEMP-R设备为护理人员提供了一种简单有效的方法,在家中准备准确的液体结核病药物悬浮剂.
- 这种方法显著改善了儿童和无法吞整片药物的患者的药物可用性.
- 该XTEMP-R设备增强了改善治疗坚持和结果在儿科结核病管理的潜力.
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