百合素通过抑制氧化应激,细胞衰老和SASPP来改善SAMP6小鼠的骨质质量
Shen Wang1,2,3,4,5, Ke Heng6, Xingchen Song1,2
1Key Laboratory of Clinical Research of Osteoporosis, Xuzhou Medical University, Xuzhou, 221300, China.
Molecular nutrition & food research
|October 26, 2023
概括
在老年性骨质疏松症的小鼠模型中,烯补充剂改善了骨健康. 它减少了氧化应激,细胞衰老和衰老相关的分泌表型,这表明骨质疏松症管理的治疗潜力.
科学领域:
- 老年学是一门学科.
- 骨生物学 骨生物学 骨生物学
- 营养科学 营养科学
背景情况:
- 细胞衰老 (CS) 和与衰老相关的分泌表型 (SASP) 是与年龄相关的骨质损失的关键因素,特别是老年骨质疏松症.
- 了解驱动老年骨质疏松症的分子机制对于开发有效干预措施至关重要.
研究的目的:
- 研究烯对老年骨质疏松症的潜在治疗作用.
- 为了确定红是否可以减轻细胞衰老和老骨中的SASP的标志.
主要方法:
- 利用老化加速小鼠倾向性6 (SAMP6) 菌株作为老年骨质疏松症的模型.
- 在SAMP6小鼠中,每天给Lycopene服用8周.
- 评估骨质量,密度,强度,微型结构,氧化应激以及骨组织中CS和SASP标记.
主要成果:
- 在SAMP6小鼠中,用莱科保存了骨质量,密度,强度和微观结构.
- 烯治疗导致骨组织内的氧化应激减少.
- 在摄入柳科后,观察到骨质细胞和骨细胞衰老的显著减少,以及SASP.
结论:
- 莱科在治疗老年骨质疏松症方面表现出有益的影响.
- 莱科的抗氧化特性似乎在调节CS和SASP方面发挥作用,从而改善骨健康.
- 莱科显示承诺作为一个饮食干预老年骨质疏松症通过抑制氧化应激,CS和SASP.
关键词:
这种药物是烯 (Lycopene).骨质疏松症是一种骨质疏松症.反应性氧物种 (ROS) 是一种反应性氧物种.衰老是一种老化.衰老加速小鼠易受影响6 (SAMP6)与衰老相关的分泌表现型 (SASP)更多相关视频
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