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甲状腺癌:一个罕见的病例和相关的不常见特征
Ajit Sahu1, Mohammed Shahin1, Priyansh Jain2
1Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India.
International journal of surgical pathology
|October 26, 2023
概括
状状甲状腺癌是一种罕见的瘤,呈现出明显的特征,使其与乳头状甲状腺癌有所区别. 这个案例突出了其独特的组织形态学和免疫组织化学特征.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 状状甲状腺癌被归类为不确定的组织生成的瘤.
- 与乳头甲状腺癌相比,这种亚型表现出明显的临床,组织形态学和免疫组织化学特征.
研究的目的:
- 报告一种罕见的cribriform morular甲状腺癌病例.
- 阐明这种特定甲状腺瘤的罕见组织学和免疫组织化学特征.
主要方法:
- 一个59岁的患有甲状腺病变的女性病人的案例研究.
- 细针吸入细胞学和全甲状腺切除样本的分析.
- 组织病理学检查,包括显微镜和免疫组织化学染色.
主要成果:
- 瘤的尺寸为9.5厘米,具有混合的cribriform和固体 morular 图案,缺乏乳头状的特征.
- 免疫组织化学显示了对β-catenin,TTF1,PAX8和雌激素受体的扩散强核阳性.
- 阴性标记物包括合成素,素,甲状腺蛋白和CDX2.2.
结论:
- 这种病例代表了一种罕见的甲状腺癌变体,具有独特的组织学和免疫组织化学标记.
- 这些发现有助于理解甲状腺瘤的差异诊断,特别是区分CMTC与乳头甲状腺癌.
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