经常性流产:男性的关键因素- 一个系统性审查和元分析
Annalisa Inversetti1,2, Arianna Bossi1, Martina Cristodoro1
1Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Andrology
|October 26, 2023
概括
精子DNA碎片化和某些精液参数与反复流产 (RPL) 有关. 评估RPL的男性因素对于理解和管理不孕症至关重要.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 遗传学 是一个遗传学.
背景情况:
- 复发性流产 (RPL) 影响1%-3%的夫妇,其中多达50%的病例仍然是异常.
- 在RPL中,父亲因素被低估了,需要采取更广泛的方法.
- 这项研究侧重于精子DNA碎片化 (SDF) 和精液参数在男性RPL因子的背景下.
研究的目的:
- 系统地审查和元分析SDF,精液参数和RPL之间的关联.
- 调查男性对重复流产的贡献.
- 提供RPL中父系因素的综合分析.
主要方法:
- 系统搜索Pubmed/MEDLINE和谷歌学者数据库 (开始至2023年2月).
- 在PROSPERO注册的协议 (ID:CRD42022278616),遵守PRISMA指南.
- 在RPL和对照组中对SDF和精液参数进行多项研究的数据的综合分析.
主要成果:
- 在RPL组中观察到更高的精子DNA碎片化率 (MD 9.21,p < 0.00001).
- 在RPL和对照组之间,射精量,精子总数,精子总运动率,渐进性精子运动率和正常精子形态学的显著差异.
- 年龄,BMI,吸烟和酒精摄入量与DNA碎片化无关;通过SDF测定和种族的亚组分析显示出一致的结果.
结论:
- 精子DNA碎片化和特定的精液参数与重复的怀孕流产有显著的关联.
- 男性因素在RPL中发挥着关键作用,突出了对其评估的需要.
- 鼓励妇科医生和泌尿科医生之间的直接合作,以全面管理RPL.
相关概念视频
Infertility in Males
276
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
276
Infertility in Females
326
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
326
Spermatogenesis
102.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.6K
Disorders of the Male Reproductive System
431
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
431
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K


