人类测量参数对亚洲人代谢功能障碍相关脂肪肝疾病的结果的影响
Kyu Yeon Choi1, Tae Yeon Kim1, Young Eun Chon1
1Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Journal of cachexia, sarcopenia and muscle
|October 26, 2023
概括
由于肌肉质量和力量较低,与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的瘦个体面临较高的动脉样硬化心血管疾病 (ASCVD) 风险. 内脏脂肪预测MAFLD患者的晚期纤维化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的健康问题.
- 人类测量参数越来越被认为是MAFLD健康结果的重要指标.
- 了解这些参数在临床结果中的作用对于患者管理至关重要.
研究的目的:
- 调查MAFLD患者临床结果的发病率和预测因素.
- 专注于人类参数与诸如动脉样硬化心血管疾病 (ASCVD) 和晚期纤维化等结果之间的关联.
主要方法:
- 从全国数据库和医院队列中分析了患有MAFLD的成年患者.
- 主要终点包括ASCVD和晚期纤维化.
- 使用后勤和考克斯回归分析来评估人类参数和终点之间的关系.
主要成果:
- 瘦身/正常体重的MAFLD患者表现出较低的肌肉质量和手握强度,但与超重/肥胖同行相比,ASCVD风险更高.
- 麻症和手握强度降低与瘦肉MAFLD患者的ASCVD风险有关.
- 肌肉质量与ASCVD风险相反相关,而内脏脂肪预测了晚期纤维化.
结论:
- 肌肉质量和力量与MAFLD患者的ASCVD风险显著相关.
- 部脂肪度在这个人群中作为先进纤维化疾病的独立预测因素.
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