抗骨质疏松症药物和心血管疾病:基于人口的全国性嵌套病例控制研究
Wen-Hsuan Tsai1, Fung-Chang Sung2,3,4, Chih-Hsin Muo2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
德诺苏马布,特里巴和双酸盐在骨质疏松症患者中显示出对心血管疾病 (CVD) 的保护作用. 激素替代疗法 (HRT) 与心血管疾病风险增加有关,指导药物选择.
科学领域:
- 骨质疏松症和心血管健康
- 药理干预药理干预
- 公共卫生研究 公共卫生研究
背景情况:
- 骨质疏松症患者面临更高的心血管疾病 (CVD) 风险.
- 有几种抗骨质疏松症药物可供使用,但它们的心血管安全性比较需要评估.
研究的目的:
- 评估与不同抗骨质疏松症药物相关的心血管疾病 (CVD) 风险.
- 在骨质疏松症患者中,比较denosumab,bisphosphonate, teriparatide和激素替代疗法 (HRT) 的心血管疾病风险.
主要方法:
- 使用台湾国家健康保险研究数据库 (2000-2016年) 进行了嵌套病例控制分析.
- 该研究包括28387名40岁以上的新诊断的骨质疏松症患者,他们使用了抗骨质疏松症药物.
- 条件后勤回归估计了使用denosumab,bisphosphonate,teriparatide和HRT的八种心血管疾病的几率比率 (ORs).
主要成果:
- 代诺苏马布使用者对整体心血管疾病的几率明显降低 (OR=0.13).
- 特里巴化物 (OR=0.52) 和双酸盐 (OR=0.80) 的使用者也显示出整体心血管疾病的几率降低.
- 激素替代疗法 (HRT) 用户出现冠状动脉疾病,外周动脉疾病,心力衰竭,肺栓塞和深静脉血栓形成的几率增加.
结论:
- 与荷尔蒙疗法相比,登诺苏马布,特里巴和双酸似乎具有对心血管疾病 (CVD) 的保护作用.
- 医疗保健提供者在为患者选择抗骨质疏松症治疗时应考虑心血管风险.
更多相关视频
07:20Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
08:21Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
Published on: July 21, 2023
相关概念视频
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Coronary Artery Disease IV: Preventive Measures
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Osteoclasts in Bone Remodeling
Cardiovascular Drugs: Classification based on Therapeutic Indications
