在绝经后妇女的多民族乳腺查队列中,与乳房扫描密度的纵向变化相关的因素
Hannah Lui Park1,2, Argyrios Ziogas3, Stephen A Feig4
1Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
The breast journal
|October 26, 2023
概括
绝经后妇女乳腺密度随时间的变化与种族和绝经年龄有关,而不是生活方式因素. 亚洲女性的密度增加,肥胖女性的密度下降,更晚的绝经年龄与稳定的密度相关.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 乳腺密度是一个重要的乳腺癌风险因素.
- 影响绝经后妇女乳腺密度变化的因素尚不清楚.
- 了解这些变化可以改善乳腺癌风险评估和预防策略.
研究的目的:
- 调查个人因素与乳腺扫描密度变化之间的关联.
- 分析绝经后妇女乳腺密度的纵向变化.
- 识别随着时间的推移导致乳腺密度增加或减少的因素.
主要方法:
- 研究了一组3392名绝经后没有乳腺癌史的女性.
- 收集的数据包括人口统计,生殖史,生活方式因素 (BMI,酒精,吸烟,体力活动) 和BI-RADS乳房扫描密度得分.
- 统计分析包括费舍尔的精确测试和多变量条件后勤回归.
主要成果:
- 85.4%的女性乳房密度没有变化;7.9%的女性乳房密度下降,6.7%的女性乳房密度增加.
- 与白人女性相比,亚洲女性的密度增加的可能性更高,密度下降的可能性更低.
- 肥胖女性不太可能增加密度,更有可能减少密度;晚期更年期年龄 (≥55) 与密度减少的可能性降低相关.
结论:
- 鉴于已知的乳腺癌风险因素,种族/肥胖和密度变化之间的观察到的关联是矛盾的.
- 更年期晚年与乳腺密度下降的可能性降低相关,与其作为乳腺癌风险因素的作用保持一致.
- 研究结果强调了乳腺密度,BMI,激素暴露和乳腺癌风险之间的复杂相互作用.
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