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循环中的microRNA与多发性硬化症患者的结构和功能MRI参数相关
Lili Geiger1,2, Gergely Orsi3,4,5, Tamás Cseh4
1Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Frontiers in molecular neuroscience
|October 26, 2023
概括
血清中的microRNA显示出可能成为多发性硬化症 (MS) 的生物标志物. 特定的microRNAs (miRNAs) 与白质病变和功能连接相关,为MS进展和神经成像发现提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 医疗成像医学成像
背景情况:
- 循环微RNAs (miRNAs) 正在成为多发性硬化症 (MS) 的有前途的生物标志物.
- 了解血清miRNA水平和神经成像参数之间的相关性对于MS诊断和监测至关重要.
研究的目的:
- 研究MS患者血清微RNA水平与各种磁共振成像 (MRI) 参数之间的关联.
- 探索miRNAs作为MS结构和功能变化的生物标志物的潜力.
主要方法:
- 招募了50名多发性硬化症患者参加该研究.
- 采集了血清样本,并使用滴滴数字PCR对十种预先选择的microRNA进行了定量分析.
- 评估了椎和大脑白质病变,区域大脑体积,白质微结构 (扩散张力成像),大脑代谢物 (磁共振光谱) 和默认模式网络功能连接 (静止状态功能MRI).
主要成果:
- 血清miR-143.3p水平在MS亚型之间有区别,在进展性MS中水平较低.
- 较高的miR-92a.3p和miR-486.5p水平与较大的椎白质病变体积相关.
- 降低miR-142.5p水平与肌素度降低有关.
- miR-92a.3p,miR-142.5p和miR-486.5p水平显示与默认模式网络功能连接相关.
结论:
- 循环中的microRNAs与MS患者的结构和功能神经成像结果都存在相关性.
- 这些发现支持血清miRNAs作为MS的非侵入性生物标志物的潜在实用性.
- 需要进一步的研究来阐明这些miRNAs在MS病原和进展中的确切作用.
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