维生素D与自杀行为的关联:系统性审查和元分析
Younes Mohammadi1,2, Nasim Ansari3, Milad Daneshi Maskooni4
1Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Iranian journal of psychiatry
|October 26, 2023
概括
低维生素D水平与更高的自杀行为风险有关,包括想象和尝试. 通过饮食或补充剂增加维生素D摄入量可能有助于降低自杀风险,尽管需要更多的研究.
科学领域:
- 营养神经科学 营养神经科学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 关于维生素D与自杀之间的关联存在不一致的发现.
- 了解这种关系对于公共卫生干预至关重要.
- 维生素D在各种神经和心理功能中起作用.
研究的目的:
- 系统地审查和对维生素D和自杀行为的现有研究进行元分析.
- 评估汇集的证据,以确定维生素D状态与自杀念头,尝试和完成之间的联系.
主要方法:
- 在主要数据库 (Scopus,Medline,Web of Science,Google Scholar) 进行系统的文献搜索,直到2022年7月.
- 在标题,摘要和全文选后,包括11项研究.
- 使用随机效应模型的元分析;通过纽卡斯尔-太华尺度评估质量;评估异质性和出版偏差.
主要成果:
- 七项研究的综合分析表明,低维生素D水平与自杀行为的可能性增加有关 (P <0.05).
- 亚组分析证实了维生素D状态与自杀念头和自杀企图 (P <0.05) 之间的显著联系.
- 观察到中等异质性 (I2=58%),没有发现显著的出版偏差 (P > 0.05).
结论:
- 这一元分析提供了支持维生素D与自杀行为之间的关系的证据.
- 维生素D水平不足可能会导致自杀行为风险.
- 建议进行进一步的研究;通过饮食或补充维生素D的摄入可能有助于降低自杀风险.
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