肝动脉输液化疗与高级肝细胞癌的全身疗法:系统性审查和元分析
Hyeon-Jong Kim1, Seung Hyuk Lee1, Hyun Jeong Shim1
1Division of Hematology-Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Frontiers in oncology
|October 26, 2023
概括
肝动脉输液化疗 (HAIC) 可以改善晚期肝细胞癌 (HCC) 患者的生存率和反应率. 需要进一步的研究来确认HAIC.
科学领域:
- 肝细胞癌研究 肝细胞癌研究
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 局部发达的肝细胞癌 (HCC) 存在治疗挑战.
- 系统化疗是一种标准治疗方法,但结果可能有限.
研究的目的:
- 评估HAIC的疗效,有或没有全身化疗,与局部发达HCC的单独全身化疗相比.
- 为了比较治疗策略之间的关键生存结果和反应率.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 搜索包括多个数据库,直到2022年12月,没有限制.
- 主要结局:总生存率 (OS),无进展生存率 (PFS) 和不良事件. 二次结果:客观反应率 (ORR) 和疾病控制率 (DCR).
主要成果:
- 分析了7个RCT,包括1010名患者,所有RCT都使用索拉芬尼作为对比剂.
- 与单独使用索拉费尼布相比,HAIC,有或没有索拉费尼布,显示了潜在的OS,PFS和ORR的改善.
- 在HAIC加索拉菲尼布和单独索拉菲尼布之间,不良事件是相似的;单独HAIC可能会减少不良事件.
结论:
- 有或没有全身化疗的HAIC可能会提高HCC患者的生存率和反应率.
- 目前的证据具有中等到非常低的确定性.
- 需要更多高质量的随机试验来验证HAIC的疗效.
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