HbA1c:一种脱甲状腺视神经病变的独立风险因素
Xing Wang1,2, Huijing Ye1, Rongxin Chen1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
糖化血红素A1c (HbA1c) 是患有甲状腺相关眼睛病症 (TAO) 的患者甲状腺视神经不全症 (DON) 的独立危险因素. 这一发现表明HbA1c可能作为早期DON预测的潜在生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 甲状腺相关眼病 (TAO) 是一种自身免疫性疾病,影响甲状腺和眼睛.
- 胰岛素耐药性 (IR) 和小岛β细胞功能障碍与TAO病变产生有关.
- 需要早期预测甲状腺视神经病变 (DON),TAO的严重并发症.
研究的目的:
- 在TAO患者中调查小岛β细胞自身抗体和IR的患病率.
- 确定可以预测DON发展的糖尿病 (DM) 指标.
主要方法:
- 一项前性横截面研究包括98名TAO患者 (57名DON,41名非DON) 和48名健康对照 (HC).
- 测量包括甲状腺功能,小岛自身抗体,禁食葡萄糖,胰岛素,C-和HbA1c.
- 后勤回归分析了患者因素和DON发生之间的相关性.
主要成果:
- 与HC和非DON组相比,DON患者的禁食血葡萄糖 (FPG) 和HbA1c水平较高.
- 在DON组中,IR的恒温模型评估 (HOMA-IR) 是最高的,而HOMA-β是最低的.
- 在对混因子进行调整后,HbA1c成为了DON的独立风险因素 (OR=4.012).
结论:
- 升高的HbA1c水平与TAO患者的DON存在独立相关.
- HbA1c显示出作为预测DON的生物标志物的潜力.
- 需要进一步的研究来探索HbA1c在DON中的作用,因为甲状腺功能障碍与DM之间存在联系.
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