在非自杀性自我伤害的青少年中对认知控制的多层次检查
Zeynep Başgöze1, Lauren Demers2, Michelle Thai3
1Department of Psychiatry & Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota.
Biological psychiatry global open science
|October 26, 2023
概括
青少年非自杀性自我伤害 (NSSI) 的严重程度与认知控制缺陷有关,包括紧迫性和响应抑制. 脑部成像显示了与NSSI严重程度相关的各种神经特征,跨越不同的认知控制措施.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 心理病理学 心理病理学
背景情况:
- 非自杀性自我伤害 (NSSI) 是青少年的一个重要行为.
- 认知控制 (CC) 缺陷,特别是响应抑制和紧迫性,与NSSI有关.
- 研究领域标准 (RDoC) 框架为研究精神病理学提供了一个维度方法.
研究的目的:
- 使用RDoC方法调查NSSI严重程度和认知控制 (CC) 之间的关系.
- 检查与青少年NSSI严重程度相关的响应抑制和紧迫性.
- 探索不同程度的NSSI严重程度的青少年中CC的神经相关物.
主要方法:
- 138名青少年女性完成了自我报告的紧急措施和Go/NoGo任务,评估了行为CC.
- 进行结构性和功能性脑成像 (休息状态和基于任务) 来评估CC网络指标.
- 相关性和回归分析检查了NSSI严重程度和多模式CC测量之间的关联.
主要成果:
- 较高的NSSI严重程度与增加的负面紧迫性和减少对积极的Go/NoGo任务的准确性相关.
- 大脑成像揭示了NSSI严重程度与CC网络激活和连接之间的复杂关联.
- 特定区域,如中间前额叶皮质,尾状皮质,背侧前额叶皮质和前带皮质,显示了与NSSI严重程度和价值相关的差异激活模式.
结论:
- 青少年NSSI严重程度与多方面的认知控制改变有关.
- 多模式神经成像和行为方法对于理解NSSI的神经生物学基础至关重要.
- 这些发现强调了认知控制在青少年精神病理学中的重要性.
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