母体皮质醇和婴儿杏仁体体积之间的关联是由社会经济地位调节的
Max P Herzberg1, Regina Triplett2, Ronald McCarthy3
1Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Biological psychiatry global open science
|October 26, 2023
概括
产前社会经济状况和母体皮质醇相互作用,影响婴儿桃体体积. 高母性皮质醇与弱势婴儿的杏仁体较小有关,但在优势婴儿中更大.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 社会经济地位 (SES) 与健康和大脑发育有关,其影响可能在产前开始.
- 产前社会经济环境和孕期环境对新生儿大脑体积的相互作用尚未得到充分理解.
研究的目的:
- 为了研究孕妇在整个怀孕期间产生的皮质醇的轨迹如何与社会经济劣势相互作用,以影响新生儿的大脑结构.
- 特别是检查杏仁体,海马体,中部前额叶皮质和尾状皮质,因为它们的皮质醇受体密度很高.
主要方法:
- 在241个母婴双中,评估了孕期三季度和新生儿大脑结构的母亲皮质醇水平.
- 研究了母亲皮质醇轨迹和大脑区域体积之间的关联.
- 包括社会经济劣势作为调节者,以了解其对皮质醇-大脑结构关系的影响.
主要成果:
- 新生儿杏仁体体积的显著预测是由母体皮质醇输出和社会经济劣势之间的相互作用.
- 对于较低社会经济劣势的母亲的婴儿,较高的母性皮质醇与较大的杏仁体体积有关.
- 相反,对于具有较高社会经济劣势的母亲的婴儿,较高的母性皮质醇与较小的杏仁体体积有关.
结论:
- 胎儿桃体发育受到母亲皮质醇产生的差异影响,这取决于社会经济优势的程度.
- 这些发现强调了产前环境在塑造婴儿大脑发育中的关键作用,包括生物 (皮质醇) 和社会 (SES) 因素.
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