胎儿前临界连接有望与幼儿的侵略性相关
Cassandra L Hendrix1, Lanxin Ji1, Denise M Werchan1,2
1Department of Child & Adolescent Psychiatry, NYU Langone Health, New York, New York.
Biological psychiatry global open science
|October 26, 2023
概括
胎儿大脑连接,特别是较弱的前边缘连接,可能会预测孩子以后的攻击性. 这一发现为攻击性行为的神经生物学起源提供了早期的见解.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 侵略性是一个重要的公共卫生问题,其起源于早期的发育.
- 目前对侵略的治疗方法是不理想的,需要更深入地了解其原因.
- 识别早期的神经生物学标志物可以为预防策略提供信息.
研究的目的:
- 为了研究胎儿大脑的功能连接性作为以后攻击性行为的预测因素.
- 为了确定与侵略的早期发作相关的候选神经电路.
主要方法:
- 在孕妇的第三个三个月中利用胎儿静止状态功能磁共振成像 (fMRI).
- 在产后3年使用儿童行为检查表 (n=79) 评估了儿童的侵略性.
- 采用独立组件分析来定义额头和边缘网络.
主要成果:
- 没有发现胎儿网络内连接 (正面或边缘) 与以后的攻击性之间存在关联.
- 皮下边缘和中间前额前额网络之间的较弱的胎儿功能合预测了3岁时母亲对儿童的侵略性增加.
- 在控制母亲情绪失调和幼儿语言能力后,这种关联仍然很重要.
- 类似的,虽然较弱的,观察到胎儿的前连接和幼儿内化症状之间的关联.
结论:
- 侵略性行为的神经相关性可能在产前检测到,在症状表现之前.
- 胎儿前连接代表了进一步调查的潜在候选神经电路.
- 这些发现可能有助于理解儿童行为发展和精神病风险.
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