精神病中的安慰剂效应:为什么它很重要以及如何测量它
Emily J Hird1, Kelly Diederen1, Stefan Leucht2
1Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Biological psychiatry global open science
|October 26, 2023
概括
了解精神病中的安慰剂效应至关重要. 确定其预测因素可以改善治疗结果,并揭示幻觉和妄想的新治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 精神病,标志着幻觉和妄想,缺乏除了抗精神病药物之外的有效治疗方法,这些药物都有局限性.
- 精神病治疗的临床试验受到显著的安慰剂反应的挑战,掩盖了真正的药物疗效.
- 强烈的安慰剂效应可以通过增加整体治疗结果,使临床实践中的患者受益.
研究的目的:
- 审查安慰剂效应在精神病治疗中的意义.
- 提出一种用于评估精神病中安慰剂效应的新方法.
- 探索精神病和安慰剂反应之间潜在的共享神经认知机制.
主要方法:
- 这项研究是对现有的关于精神病和安慰剂效应的文献进行叙事性审查.
- 它检查了安慰剂反应对精神病临床试验所带来的挑战.
- 它提出了一个新的框架来量化和理解精神病中的安慰剂效应.
主要成果:
- 安慰剂效应显著影响精神病临床试验,使抗精神病疗效的评估复杂化.
- 对安慰剂效应的生物标志物已在其他疾病中确立,但尚未在精神病中确定.
- 假设精神病和安慰剂反应之间有一个共享的神经认知机制,涉及信仰更新过程.
结论:
- 确定安慰剂效应的预测因素可以提高精神病治疗的疗效,并为临床试验设计提供信息.
- 研究精神病和安慰剂机制之间的重叠可能会揭示新的治疗目标.
- 开发量化安慰剂效应的方法对于推进精神病研究和治疗至关重要.
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