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背中体中的活动是概率不确定性下序列逆转学习表现的基础
Madison K Young1, Kyna-Anne Conn1, Joyosmita Das1
1Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Biological psychiatry global open science
|October 26, 2023
概括
变化的背中条体 (DMS) 活动会损害逆向学习,特别是在不确定性条件下. 这表明DMS中多巴胺的升高可能是精神病决策缺陷的基础.
科学领域:
- 神经科学是一个神经科学.
- 计算精神病学是一种计算精神病学.
- 行为神经科学 行为神经科学
背景情况:
- 皮层状回路,包括背中状体 (DMS) 和侧轨道前皮层,对于在概率不确定性下逆向学习至关重要.
- 在精神病中观察到这些回路的损伤和逆向学习,这表明共享的神经生物学基础.
- 这项研究调查了皮质干活动在与精神病相关的逆转性学习缺陷中的作用.
研究的目的:
- 检查背中状体 (DMS) 活动在逆向学习中的因果作用.
- 为了研究精神刺激剂诱导的精神病相关的神经生物学如何影响在逆向学习期间的皮质状回路.
- 为了确定DMS激活在不同概率突发事件下对逆向学习的影响.
主要方法:
- 在雄性小鼠中利用安非他胺治疗在逆向学习过程中模拟精神病相关的神经生物学.
- 采用化学遗传学来特别激活中脑输入到DMS,评估逆向学习中的因果作用.
- 检查了特定途径的皮质前皮质激活及其对概率突发事件的依赖.
主要成果:
- 接受胺治疗的小鼠表现出受损的惩罚学习,减少损失后的转移,并在逆转学习期间增加了坚持性错误.
- 侧面轨道前皮层对DMS电路和DMS本身增加的活动调节了反向学习性能和策略.
- 直接激活中脑到DMS电路损害了损失后的转移和整体逆转学习,取决于概率不确定性.
结论:
- 背中条体 (DMS) 在逆向学习中起着复杂的作用,活动增加会损害取决于不确定性的过程.
- 在逆向学习过程中,DMS活动对于保持和选择皮质输入至关重要.
- DMS中多巴胺水平升高可能导致精神病患者观察到的决策障碍.
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