社会健康与社区老年人的特定脑管白质微观结构有关
Andrea Costanzo1, Isabelle F van der Velpen2,3, M Arfan Ikram2
1Groningen Institute for Evolutionary Life Sciences, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands.
Biological psychiatry global open science
|October 26, 2023
概括
糟糕的社会健康与大脑变化有关. 孤独会影响边缘和感官运动系统,而社会支持会影响协会和 commissural 系统,从而揭示出不同的神经通路.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 神经成像是一种神经成像.
背景情况:
- 糟糕的社会健康是神经精神疾病的危险因素.
- 神经成像研究表明,社会健康与白质完整性之间存在联系.
- 这项研究确定了参与社会健康协会的特定白质区域.
研究的目的:
- 研究社会健康标志物与白质微观结构之间的关联.
- 为了确定受孤独和社会支持影响的特定白质片段.
- 探索这些关联中的性别差异.
主要方法:
- 利用了3352名参与者在鹿特丹研究 (2002-2008) 的数据.
- 使用孤独感,感知到的社会支持和伙伴关系状态来评估社会健康.
- 分析了15个通道的白质微结构完整性,使用扩散核磁共振和通道学.
- 用多变量线性回归来进行横截面分析.
主要成果:
- 孤独与较高的平均扩散度 (MD) 在上方体辐射和环膜相关.
- 感知到的社会支持与小子,下面的前后骨和未骨中较低的MD有关.
- 性别特定的发现包括男性的社会支持和子小MD之间的关联,以及女性的孤独和高级乳头辐射MD.
结论:
- 社会健康与特定的白质微结构通路有关.
- 孤独会影响边缘和感官运动系统,而社会支持会影响协会和 commissural 系统.
- 这些发现突出了社会健康的不同领域的不同神经基质.
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