涉及多个部位的高血压中介器官损伤是心血管事件的独立风险因素
Maria Lembo1, Daniela Pacella2, Maria Virginia Manzi1
1Department of Advanced Biomedical Sciences, Federico II University of Naples, Via S. Pansini 5, 80131 Napoli, Italy.
European heart journal open
|October 26, 2023
概括
多个部位的高血压介导器官损伤 (HMOD) 在高血压患者中显著增加主要不良心血管事件 (MACE) 风险. 代谢失调也会导致这种心血管风险增加.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
背景情况:
- 慢性压力过载导致高血压介导器官损伤 (HMOD),影响多个器官.
- 在高血压患者中,HMOD是心血管发病率和死亡率的重要因素.
研究的目的:
- 评估HMOD存在和程度对主要心血管不良事件 (MACE) 的预后影响.
- 评估血压和新陈代谢控制在高血压患者HMOD的作用.
主要方法:
- 来自坎帕尼亚健康网络注册表的7237名高血压患者的分析.
- 在左心室缩,动脉斑块和慢性病中评估HMOD.
- 利用Cox多变量模型来评估与MACE的关联,并根据临床因素进行调整.
主要成果:
- 随着HMOD地点的数量增加,MACE率增加了2.7% (没有HMOD) 到9.8% (三个地点).
- 主要不良心血管事件与年龄,代谢失调 (METS-IR) 和多个HMOD部位显著相关.
- 在57.3%的患者中,达到最佳的血压控制.
结论:
- 随着HMOD部位的数量增加,MACE的风险随着血压控制的独立性而升级.
- 涉及多个部位的高血压中介器官损伤是MACE的独立风险因素.
- 代谢失调显著导致高血压患者的心血管风险HMOD.
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