后COVID-19并发症和随访生物标志物
Muhammad Abdullah1, Amjed Ali2, Muhammad Usman3
1Institute of Molecular Biology and Biotechnology, University of Lahore Pakistan.
Nanoscale advances
|October 26, 2023
概括
后COVID-19综合征影响数百万,导致持续的症状,如疲劳和认知问题. 了解生物标志物上调是预防COVID-19幸存者的长期并发症的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 由于COVID-19大流行,大量幸存者经历了长时间的症状,称为后COVID-19综合征.
- 据估计,英国约有 130 万人报告了持续症状,持续时间约为四周.
- 常见的症状包括疲劳,呼吸道问题,认知障碍,嗅觉或味觉下降.
研究的目的:
- 研究特定生物标志物在COVID-19后并发症发展中的作用.
- 了解COVID-19幸存者的器官衰竭和系统性并发症背后的机制.
- 确定潜在的治疗点,以防止COVID-19后病情恶化.
主要方法:
- 对大量人口队列中自我报告的症状的分析.
- 审查有关COVID-19生理影响的现有文献.
- 识别上调生物标志物,包括P (SP) 物质和各种细胞因子 (TNF-α,IL-6,IL-10,IL-1β,ACE2,CCL3).
主要成果:
- 后COVID-19并发症经常涉及呼吸道,心脏,神经,心理和肌肉骨系统.
- 幸存者的器官损伤与缺氧和炎症有关.
- SP和特定细胞因子的升级与广泛的系统性并发症有关.
结论:
- 该研究强调了COVID-19的复杂多系统影响.
- 准SP和细胞因子等高调生物标志物可能对于管理和预防COVID-19后的长期并发症至关重要.
- 进一步研究阻止这些生物标志物受体是有必要的,以改善幸存者护理.
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