急性间歇性炎的变化潮流:印度南部的一项回顾性观察性研究
Mythri Shankar1, Sreedhara C Gurusiddaiah1, Seeta Mutalik1
1Department of Nephrology, Institute of Nephro-Urology, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.
Indian journal of nephrology
|October 26, 2023
概括
急性间歇性炎 (AIN) 越来越常见,特别是在老年人中. 虽然大多数患者康复,脏范围蛋白尿症表明进展到慢性病的风险更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内部医学 内部医学
- 病理学 病理学 病理学
背景情况:
- 全球急性间歇性炎 (AIN) 发病率正在上升.
- AIN的原因和结果表现出时间和地理差异.
研究的目的:
- 分析活检证明的AIN的趋势,原因和结果.
- 为了确定与AIN进展相关的因素.
主要方法:
- 对6234个本地细胞活检 (2016-2021) 的回顾性观察性研究.
- 包括活检证明的AIN病例,不包括与全身性疾病或异位移植有关的病例.
- 分析了患者的人口统计,药物史,临床表现和结局.
主要成果:
- 156个AIN病例被确定;主要在第六个十年和男性.
- 50%的患者有药物服用史,其中特诺福维尔是最常见的.
- 96.2%的患者患有急性损伤 (AKI);79.5%的患者完全康复,19.2%的患者进展为慢性病.
结论:
- AIN是AKI的重要原因,特别是在老年人中.
- 药物,包括HAART,是主要的AIN触发器.
- 脏范围蛋白尿在呈现时预测慢性病的进展.
相关概念视频
Acute Kidney Injury IV: Diagnostic Studies and Prevention
19
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
19
Acute Pyelonephritis II: Diagnostic Studies and Management
15
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
15
Acute Pyelonephritis I: Introduction
20
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
20
Acute Kidney Injury II: Pathophysiology
10
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
10
Acute Kidney Injury III: Clinical Manifestations
13
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
13
Acute Kidney Injury I: Introduction
14
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
14


