血液,肠道和口腔微生物组在移植接受者
Susana Sampaio1,2,3,4, Ricardo Araujo1,2, Ana Merino-Riba1,2,5,6,7
1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, EPE, Portugal.
Indian journal of nephrology
|October 26, 2023
概括
移植接受者 (KTRs) 具有独特的血液微生物组,与肠道和口腔微生物组不同. 这种低丰度的血液微生物组主要由蛋白质细菌和固菌菌组成,其潜在的临床相关性需要进一步研究.
科学领域:
- 微生物学 微生物学
- 移植免疫学 移植免疫学
- 基因组学就是基因组学.
背景情况:
- 新出现的证据表明,非传染性血液微生物组.
- 人类微生物组的失生与慢性病和移植结果有关.
- 了解移植接受者 (KTRs) 的微生物组变异至关重要.
研究的目的:
- 为了研究KTRs的肠道,口腔和血液微生物组概况.
- 为了探索这些微生物组之间的变异和相关性,移植后3个月.
- 描述KTRs血液微生物组的独特特征.
主要方法:
- 横截面研究设计. 截面研究设计.
- 来自6个KTR的便,唾液和血液样本的分析.
- 使用Illumina MiSeq技术进行16S rRNA基因测序 (V3-V4区域).
主要成果:
- KTRs表现出一个独特的,低丰度的血液微生物组.
- 血液微生物组主要由蛋白质细菌和固菌细菌主导.
- 肠道和口腔微生物群也表现出不同的特征,其中一些共享的操作分类学单位 (OTU) 主要是蛋白质细菌和固体细菌.
结论:
- 证据支持在KTRs.中存在独特的血液微生物组.
- 这种血液微生物组不同于肠道和口腔微生物组.
- 一小部分共享的OTU存在于身体各个部位;临床意义需要进一步调查.
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