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基于生物外的模仿病毒体与聚合物外纳米颗粒的比较,用于增强口服胰岛素的输送

Zhixiang Cui¹, Shuman Cui¹, Lu Qin¹

¹School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.

Asian journal of pharmaceutical sciences

|October 26, 2023

概括

模仿病毒的纳米颗粒显示出可以提供口服胰岛素的潜力. 与聚合物外设计相比,生物外纳米颗粒表现出优异的粘液透和血糖调节,突出了药物吸收的结构重要性.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

口服胰岛素的输送因肠道粘液屏障而面临挑战.
模仿病毒囊的纳米粒子提供了一种克服这一障碍的策略.
不同病毒模仿结构对纳米粒子性能的影响尚未得到充分理解.

研究的目的:

设计和评估模仿病毒的纳米粒子,具有独特的外结构,用于口服胰岛素的输送.
研究生物外与聚合物外结构对纳米粒子粘膜透和细胞吸收的影响.
评估不同纳米粒子设计的体内低血糖疗效.

主要方法:

生物素移植的奇托桑纳米颗粒的自组装,采用链条维丁 (生物) 或氨酸/酸盐 (聚合物) 涂层.
评估肠经粘液和肠经粘膜透效率.
通过内细胞分裂路径分析,研究细胞吸收机制.
在动物模型中评估体内低血糖效应.

主要成果:

生物外纳米颗粒在10分钟内实现了>80%的肠道透粘透.
与聚合物外对应物相比,生物外纳米颗粒显示出1.6-2.2倍更高的跨粘膜透效率.
生物外纳米颗粒通过洞穴介导的内细胞分解被吸收,而聚合物外纳米颗粒利用了克拉介导的内细胞分解,导致潜在的溶酶体降解.
在体内研究表明,生物纳米颗粒提供了最好的血糖调节 (5.1%的改善).

结论:

病毒体模仿纳米颗粒的外部结构显著影响它们的粘膜透和细胞吸收机制.
与聚合物外纳米颗粒相比,生物外纳米颗粒在口服胰岛素输送方面表现优越.
这些发现强调了结构设计在工程纳米颗粒中对有效的口服药物吸收和体内疗效的重要性.

关键词:

粘液透性透性粘液透性粘液粘液是一种粘液.纳米颗粒纳米颗粒口服胰岛素是可以服用的.在Streptavidin中使用.模仿病毒的病毒模仿

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