多参数MRI用于评估脏结构,功能和内源代谢物的变化,用于因缺血症引起的急性损伤的动物模型
Quan Tao1,2,3, Qianqian Zhang2,3,4, Ziqi An2,3,4
1Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Journal of magnetic resonance imaging : JMRI
|October 26, 2023
概括
多参数MRI (mpMRI) 纵向评估缺血性再注射损伤 (IRI-AKI) 后的损伤. 氨基化学交换和转移 (CEST) 显示了IRI-AKI的最高诊断准确性.
科学领域:
- 磁共振成像是一种磁共振成像技术.
- 脏生理学 脏生理学
- 生物医学工程 生物医学工程
背景情况:
- 缺血重灌损伤 (IRI) 可以导致急性损伤 (AKI).
- 准确检测IRI-AKI仍然是一个挑战.
- 这项研究旨在纵向评估大鼠的IRI-AKI.
研究的目的:
- 用多参数MRI (mpMRI) 在老鼠中纵向评估IRI-AKI.
- 评估脏结构,功能和代谢物.
- 为了确定IRI-AKI诊断的敏感MRI指标.
主要方法:
- 48只大鼠接受了IRI-AKI诱导.
- 纵向的mpMRI在多个时间点 (0-28天) 进行.
- mpMRI序列包括T1映射,ASL,BOLD,T2映射,qMT和CEST. 这三种类型的图像.
主要成果:
- 在IRI脏中,T1和T2值增加,在第14天达到峰值.
- 在第3天之后,脏血流 (RBF) 显著下降.
- 氨基CEST显示了IRI-AKI的最高诊断准确度 (AUC=0.899) .
结论:
- mpMRI可以全面评估IRI-AKI变异.
- 氨基CEST是IRI-AKI诊断的一个有前途的生物标志物.
- 这种技术有助于理解IRI-AKI的进展.
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