种族和种族对多发性骨髓瘤早期死亡率的影响:SEER分析
John X Wei1, Aditi Shastri2, R Alejandro Sica2
1Department of Medicine, Montefiore/Albert Einstein College of Medicine, New York.
Haematologica
|October 26, 2023
概括
诸如年龄较大,男性性别和少数群体地位等社会人口统计学因素增加了多发性骨髓瘤患者的早期死亡 (EM) 风险. 这些差异无论收入如何都会持续存在,这凸显了针对性干预的关键需求.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 多发性骨髓瘤治疗的重大进展在过去二十年中改善了整体存活率.
- 然而,大量患者仍然面临早期死亡 (EM),定义为诊断后两年内死亡.
- 这表明,生存率的改善可能不会在所有患者的人口统计学中均分布.
研究的目的:
- 研究社会人口学因素对多发性骨髓瘤早期死亡率的影响.
- 为了确定特定的患者群体在诊断后易受早期死亡的影响.
- 探索这个患者群体中种族,收入和早期死亡率之间的关系.
主要方法:
- 利用了从监测流行病学和最终结果 (SEER) 数据库中的数据,涵盖2000-2019年.
- 采用回归建模来分析社会人口学变量与早期死亡率之间的关联.
- 进行了子组分析,以检查收入对早期死亡率种族差异的影响.
主要成果:
- 高龄,男性性别和少数民族种族地位 (非西班牙裔黑人,西班牙裔) 与更高的早期死亡率有关.
- 少数民族地位也是较差的2年总生存率的重要预测因素.
- 种族和早期死亡率之间的关系与收入无关,这表明除了获得护理之外的因素有助于造成差异.
结论:
- 社会人口统计学因素,特别是种族,在多发性骨髓瘤患者的早期死亡风险中起着至关重要的作用.
- 确定了需要有针对性的干预措施以减轻生存差异的特定弱势群体.
- 需要进一步的研究来了解和解决多发性骨髓瘤护理中这些不平等的根本原因.
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