在年轻,健康的成年人中,β-酸对左心室功能的急性影响
Andrew P Oneglia1, Benjamin E Young2, Daisha J Cipher3
1Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|October 26, 2023
概括
外源乙醇在健康个体中增加心脏输出,主要是通过增加心率,而不是收缩性. 这项研究阐明了类素作为心脏燃料的作用.
科学领域:
- 心脏病学 心脏病学
- 代谢研究研究 代谢研究
- 运动生理学 运动生理学
背景情况:
- 类被探索为心脏燃料,在心力衰竭中具有潜在的益处.
- 外源子的使用与心脏输出量增加有关.
- 准确的机制和对心力衰竭状态的依赖是不清楚的.
研究的目的:
- 为了研究口服乙醇对年轻健康志愿者的心脏功能的影响.
- 为了确定心脏输出量的增加是由于收缩率或心率的变化.
- 评估基在心脏机制中的作用,独立于心力衰竭.
主要方法:
- 随机,双盲,安慰剂控制的研究设计.
- 对健康的年轻成年人进行口服类 Ester 的使用.
- 心脏磁共振成像评估左心室功能超过60分钟.
主要成果:
- 摄入子显著增加了循环中的β-基酸盐水平.
- 心脏输出量在摄入子后增加了大约1L/分钟.
- 心脏输出量的增加主要是由心率升高 (慢性变异) 驱动的,中风体积的轻微变化 (异性变异).
结论:
- 急性酸升高可增强健康个体的心脏输出.
- 主要机制是慢性 (心率),具有有限的内热性 (收缩性) 贡献.
- 心脏MRI数据表明,内性在这种反应中起的作用很小.
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