长期使用芬特明的人群中与芬特明的潜在药物相互作用:回顾性分析
概括
在南非,长期使用芬特明与许多中度和严重的药物相互作用有关. 由于这些相互作用,接受长期青素治疗的患者可能会出现不良反应,这突显出严重的公共卫生问题.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 公共卫生 公共卫生
背景情况:
- 胺,一种安非他胺衍生物,用于短期的肥胖管理,由于潜在的心血管风险,滥用和长期 (LT) 使用的依赖.
- 长期使用芬特明 (连续超过12周) 与潜在的药物相互作用 (PDDI) 和药物不良反应 (ADR) 有关.
- 芬太胺经常被处方为LT和非标签,增加了不良药物事件 (ADEs) 和药物相互作用 (DDIs) 的风险.
研究的目的:
- 为了确定与长期的芬特明治疗相关的轻度,中度和严重的药物相互作用 (DDI) 的患病率.
- 调查南非超过连续12周的丁胺联合处方模式.
主要方法:
- 一项跨部门药物利用审查 (DUR) 分析了来自南非药房福利管理 (PBM) 数据库 (2015年1月 - 2019年12月) 的回顾性药物索赔数据.
- 根据供应持续时间确定了连续12周以上服用芬特明的患者.
- 使用药物相互作用检查器 (Drugs.com) 识别了潜在的轻度,中度和严重的DDI.
主要成果:
- 在长期服用芬特明的889名患者中,75% (20人中15人) 患有中度PDDI,25% (20人中5人) 患有严重PDDI.
- 德克斯特罗梅索芬是中度DDI组中最常见的联合处方药 (31.72%),而特拉马多尔在严重DDI组中最常见 (46.79%).
- 在前20个联合处方药中没有发现轻微的PDDI.
结论:
- 患者正在接受长期的芬特明治疗,尽管存在中度和严重药物相互作用的重大风险.
- 与其他药物同时使用芬特明增加了由于DDI而经历药物不良反应的可能性.
- 该研究强调,需要对长期服用芬太明的患者进行仔细监测和管理,以减轻与药物相互作用相关的风险.
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