一个桶中的两个正方形:为子[6]uril的轴向取代的形状刚性亚利法结合基因
Kristýna Jelínková1,2, Aneta Závodná1, Jiří Kaleta2
1Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 5669, Zlín 760 01, Czech Republic.
The Journal of organic chemistry
|October 26, 2023
概括
研究人员为超分子化学开发了新的刚性,异形结合基因. 这些新型客人对库库比图里尔 (CB6/7) 和环极素 (CDs) 具有很高的选择性,使先进的分子装置成为可能.
科学领域:
- 超分子化学 超分子化学
- 主机和客人的化学反应
- 材料科学 材料科学 材料科学
背景情况:
- 超分子化学需要新的结合基因来构建复杂的分子设备,如传感器和催化剂.
- 现有的固的,形结合基因为库库比图里尔 (CBs) 允许轴性取代是有限的.
研究的目的:
- 为了合成和表征新的刚性,为高分子宿主-客体复合的异形结合动机.
- 评估这些新型图案与黄素[6]uril (CB6),黄素[7]uril (CB7) 和环极素 (CD) 的结合特性.
主要方法:
- 合成了三种模型客体,其中包括螺旋[3.3]和双环[1.1.1]核与伊米达和 termini.
- 使用核磁共振 (NMR) 光谱,定位热度计,质谱和单晶X射线衍射的结合性研究.
主要成果:
- 一个 bisimidazolio spiro[3.3]heptane 客体与 CB6,CB7 和 β-cyclodextrin 形成了包含综合体,其关联常数 (K) 从 1.4 × 10^2 到 1.2 × 10^12.
- 一种二模拟物表现出与CB6 (K = 1.4 × 10^6) 和CB7 (K = 3.8 × 10^12) 的增强结合,这是由于末端组的硬化阻碍较小.
- 一个比西米达二环[1.1.1]客体显示出高度选择性和强大的结合,仅与CB7结合 (K = 1.1 × 10 ^ 11).
结论:
- 新开发的基于spiro[3.3]heptane和bicyclo[1.1.1]pentane的结合基因显示出超分子化学的巨大潜力.
- 在复杂形成中观察到的高选择性与cucurbiturils和cyclodextrins表明它们在设计先进的多类型超分子组件中的实用性.
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