通过热氧化反应制造聚烯纳米塑料 对于人类细胞的反应性研究
Suphatra Hiranphinyophat1, Tomoki Hiraoka1, Mako Kobayashi1
1Graduate School of Engineering, Tohoku University, 6-6-2 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi 980-8579, Japan.
Langmuir : the ACS journal of surfaces and colloids
|October 26, 2023
概括
研究人员创建了氧化聚烯纳米塑料 (OPP) 来研究它们对环境和健康的影响. OPPs对人类肠道细胞呈现细胞毒性,突出显示需要对纳米塑料风险进行进一步研究.
科学领域:
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 纳米塑料 (NP) 由于广泛使用塑料,造成越来越多的环境和公共健康风险.
- 聚烯 (PP) 是工业和医疗领域的常见塑料,但缺乏用于PP NP检测和研究的标准化方法.
- 了解PP NP对生物系统的影响是有限的.
研究的目的:
- 为环境和生物影响研究制造氧化聚烯纳米塑料 (OPPs) 的模型.
- 描述制造的OPPs的物理和化学特性.
- 评估OPPs在人肠细胞上的体外细胞毒性.
主要方法:
- 隔离性聚烯 (iPP) 在各种温度下使用过氧化 (H2O2) 进行氧化,以创建OPPs.
- OPP的特点是尺寸分布,表面化学 (FTIR,XPS),形态和热特性.
- 对OPP175 (在175°C产生OPPs) 的细胞毒性,以剂量依赖的方式对Caco-2细胞进行了评估.
主要成果:
- 随着反应温度的增加,OPP的大小减少;OPP175的平均直径约为0.14 ± 0.02μm.
- 氧化显著增加了碳含量,由FTIR和XPS证实.
- 在100μg/mL的OPP175.5下观察到Caco-2细胞活性的显著损失.
结论:
- 建立了一种制造模型聚烯纳米塑料 (OPP) 的方法.
- OPP对人类肠道细胞具有度依赖的细胞毒性.
- 这项研究为进一步对纳米塑料风险的体外和体内研究提供了基础.
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