自闭症成年人对随机对照试验的设计和过程的看法:APRiCoT研究
Lucy Beasant1, Alba Realpe1,2, Sarah Douglas3
1University of Bristol, UK.
Autism : the international journal of research and practice
|October 26, 2023
概括
自闭症成年人通常接受心理健康研究的随机对照试验 (RCT),但对治疗的不确定性和过去的医疗保健经验表示担忧. 对自闭症个体的早期和持续参与对于设计包容性和可信赖的临床试验至关重要.
科学领域:
- 临床试验 临床试验
- 自闭症谱系障碍研究研究
- 心理健康干预 心理健康干预
背景情况:
- 大型随机对照试验 (RCT) 是评估医疗保健治疗的标准.
- 对于自闭症成年人有效的心理健康治疗,大量的RCT显著缺乏.
- 自闭症成年人的观点对于设计相关和有效的临床试验至关重要.
研究的目的:
- 探索自闭症成年人对随机对照试验 (RCT) 的看法.
- 为未来关于自闭症成年人焦虑药物的RCT设计提供信息.
- 了解RCT方法论的意见,包括参与者选择和研究执行.
主要方法:
- 定性研究涉及49名自闭症成年人的个人访谈.
- 探索参与者对RCT公平性和基于证据的性质的意见.
- 识别参与RCT的自闭症成年人的潜在障碍和促进因素.
主要成果:
- 大多数自闭症成年人认为RCT是可以接受的,赞赏其公平性和证据基础.
- 由于过去的负面医疗经验,人们对治疗的不确定性和潜在的脆弱性表示担忧.
- 清晰而准确的沟通对于建立信任和改善研究获取至关重要.
结论:
- 进行大规模的RCT是可行的,包括自闭症患者和自闭症患者.
- 自闭症个体在试验设计中的早期和持续参与至关重要.
- 解决参与者的担忧可以提高RCT在自闭症心理健康研究中的包容性和成功.
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