在接受免疫治疗的患者中,淋巴结大小和超级进展之间是否存在关联?
Mohammad S Alkader1, Rashed Z Altaha2, Eslam H Jabali3
1Department of Clinical Oncology, Military Cancer Center, Royal Medical Services, Amman, Jordan.
概括
在接受免疫治疗的患者中,治疗前淋巴结 (LN) 尺寸较大 (≥3厘米) 与超进展性疾病 (HPD) 有关. 这种关联可能会预测癌症患者的治疗结果更差,总体存活时间更短.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症研究 癌症研究
背景情况:
- 超渐进性疾病 (HPD) 是一些接受免疫检查点抑制剂 (ICI) 的患者的瘤生长和临床衰退的快速加速.
- 在接受ICI的患者中,HPD发生率差异很大 (5.9%43.1%).
- 确定HPD的预测因素对于及时干预和改善患者结果至关重要.
研究的目的:
- 调查淋巴结 (LN) 大小与转移性细胞癌 (mRCC) 患者的HPD发展之间的关联.
- 确定预处理LN大小切割值为3厘米是否可以预测HPD.
主要方法:
- 对十名mRCC患者的回顾性分析.
- 基于既定标准的HPD识别.
- 费舍尔精确测试用于评估LN大小 (≥3厘米) 和HPD之间的关联.
- 卡普兰-梅尔总体存活时间 (OS) 的分析与比较.
主要成果:
- 30%的患者患有高血压.
- 在HPD和LN大小≥3厘米 (p=0.008) 之间发现了统计学上显著的关联.
- 与非HPD患者相比,患有HPD的患者的平均存活期 (3个月) 显著缩短 (OS未达到,P=0.001).
结论:
- 治疗前的淋巴结大小≥3厘米与HPD发展有显著的关联.
- 在接受免疫治疗的mRCC患者中,LN大小可以作为HPD的预测生物标志物.
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