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血清素2C受体在雄性小鼠的头部抽反应中也很重要

Raly James Perez Custodio¹, Darlene Mae Ortiz², Hyun Jun Lee²

¹Networking Group Aging, Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors - IfADo, Ardeystrasse 67, Dortmund, 44139, Germany. custodio@ifado.de.

Psychopharmacology

|October 26, 2023

概括

研究了像MAL和BOD这样的迷幻药物对血清激素受体的激活. 研究结果显示,5-HT2A和5-HT2C受体都会启动头部抽反应,而5-HT2C也显示出神经毒性潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

血清性迷幻药激活了血清受体,主要是5-HT2A,以诱导像头部抽反应 (HTR) 这样的效应.
5-HT2A受体激活在启动迷幻效应中的确切作用仍在研究中,因为并非所有激动剂都表现相同.

研究的目的:

在雄性小鼠中区分血清素2A (5-HT2AR) 和2C (5-HT2CR) 受体在介导由甲基 (MAL) 和4-甲基-2,5,β-trimethoxyphenethylamine (BOD) 诱导的HTR中的作用.
评估MAL和BOD的潜在神经毒性特性.

主要方法:

雄性小鼠接受了MAL和BOD,并评估了HTR和神经毒性.
药理学阻断,药物亲和力和分子分析进行,以证实行为观察.
在雄性小鼠中,DOI被用作HTR的阳性对照.

主要成果:

5-HT2CR的激活,独立或与5-HT2AR一起,产生了可比的HTR在1mg·kg-1.1.
对5-HT2CR和5-HT2AR观察到不同的信号通路 (Gqα11).
在30毫克·公斤-1时,化合物表现出增强的神经毒性,与激活的促炎细胞因子有关.

结论:

5-HT2AR是HTR的主要发起者.
5-HT2CR还具有独特的特性,使其能够在雄性小鼠中有效诱导HTR.
这项研究突出了血清素受体在调解类似迷幻药的效果和相关的神经毒性的复杂相互作用.

关键词:

身体身体身体头部抽反应的反应炎症炎症是一种炎症.马尔马尔马尔马尔梅斯卡林 (Mescaline) 是一种制剂.新型精神活性物质新型精神活性物质乙烯胺是什么类型的

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